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Bupropion 150 mg for weight loss in adult patients with major depressive disorder (MDD). A double-blind comparison study of parenteral bupropion (2.5 mg) and placebo. The effects of parenteral bupropion (2.5 mg) were compared with placebo on self-reported and objective measures of symptom severity and remission in patients aged 18 to 70 years with DSM-IV Major Depressive Disorder []. Patients were